1.基本信息
刘长海，1987年2月生，山东费县人，教授，博士生导师。2009年本科毕业于青岛农业大学园艺专业；2012年硕士毕业于维多利亚vic115优惠大厅果树学专业；2016年博士毕业于丹麦哥本哈根大学植物病理学专业。2016年7月到维多利亚vic115优惠大厅工作至今。
2.研究方向
苹果-病原真菌互作、苹果抗/感真菌病害基因挖掘、苹果抗病性调控等研究。
（1）苹果树腐烂病菌、炭疽叶枯病菌、镰孢菌等效应因子致病机理
（2）苹果抗/感真菌病害关键基因挖掘与作用机制解析
（3）苹果抗病调控技术及种质创新
3.开设课程
讲授本科生“园艺植物生物技术”、“果树生理学”、“园艺植物栽培学总论”、“果树栽培学总论”等理论教学和“园田操作技能训练”、“果树夏季管理”、“科技市场调查”等实践课程；讲授研究生“现代果树科学进展”和全英文课程“园艺植物逆境功能基因组学”。
4.科研项目
（1）自噬参与ABA诱发腐烂病抗性因子MdLYK10降解的分子机制解析，国家自然科学基金面上项目，32172529，2022.1-2025.12，58万，主持
（2）苹果抗逆矮化砧木选育，陕西省科技重大专项，2020zdzx03-01-01，2019.8-2023.12，145万，子课题主持
（3）果树应答真菌病害的分子机制，国家重点研发计划项目，2018YFD1000300，2018.10-2022.09，46万，子课题主持
（4）RNA结合蛋白MdYTP2在苹果抗褐斑病应答中的功能和作用机制解析，国家自然科学基金青年项目，31701897，2018.01-2020.12，25万，主持
（5）苹果PI4Kγ2在抗腐烂病中的功能及其mRNA降解机制解析，中国博士后科学基金第11批特别资助, 2018T111108，2018.03-2020.02，15万，主持
（6）苹果褐斑病感病基因MdYTP2的表达调控机制解析，中国博士后科学基金第61批面上一等资助，2017M610657，2017.03-2019.03，8万，主持
（7）苹果MhYTP2与MhARD4互作负调控褐斑病抗性机理研究，陕西省自然科学基础研究计划项目，2018JQ3008，2018.011-2019.12，3万，主持
（8）杨凌示范区科技计划项目，2017.11-2019.10，10万，主持
（9）中央高校基本科研业务费，2017.05-2019.04，10万，主持
（10）维多利亚vic115优惠大厅博士科研启动项目，2016.07-2019.06，20万，主持
5.发表论文 (#共同第一作者，*共同通讯作者)
(26) Tingting Pei, Dongshan Niu, Yongxin Ma, Minghui Zhan, Jie Deng, Pengmin Li, Fengwang Ma*, Changhai Liu*. 2024. MdWRKY71 promotes the susceptibility of apple to Glomerella leaf spot by controlling salicylic acid degradation. Molecular Plant Pathology , 25, e13457.
(25) Tingting Pei#, Minghui Zhan#, Dongshan Niu, Yuerong Liu, Jie Deng, Yuanyuan Jing, Pengmin Li*, Changhai Liu*, Fengwang Ma*. 2024. CERK1 compromises Fusarium solani resistance by reducing jasmonate level and undergoes a negative feedback regulation via the MMK2-WRKY71 module in apple. Plant, Cell & Environment , 47, 2491–2509.
(24) Runmin Che#, Changhai Liu#, Qi Wang, Wenyan Tu, Ping Wang, Chao Li, Xiaoqing Gong, Ke Mao, Hao Feng, Lili Huang, Pengmin Li & Fengwang Ma*. 2023. The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. Autophagy . 19:6, 1745-1763.
(23) Tianli Guo#, Changhai Liu#, Fanxin Meng, Liu Hu, Xiaomin Fu, Zehua Yang, Na Wang, Qi Jiang, Xiuzhi Zhang, Fengwang Ma*. 2022. The m6A reader MhYTP2 regulates MdMLO19 mRNA stability and antioxidant genes translation efficiency conferring powdery mildew resistance in apple. Plant Biotechnology Journal , 20(3): 511-525.
(22) Yubo Sun#, Danyan Luo#, Yuerong Liu, Wenyan Tu, Runmin Che, Hao Feng, Lili Huang, Fengwang Ma*, Changhai Liu*. 2024. Valsa mali effector Vm_04797 interacts with the adaptor protein MdAP-2β to manipulate host autophagy. Plant Physiology. 195:502–517.
(21) Runmin Che, Yuerong Liu, Shengqi Yan, Chao Yang, Yubo Sun, Changhai Liu*,Fengwang Ma*. 2023. Elongation factor MdEF-Tu coordinates with heat shock protein MdHsp70 to enhance apple thermotolerance. The Plant Journal. doi: 10.1111/tpj.16561.
(20) Yuanyuan Jing, Tingting Pei, Chunrong Li, Duanni Wang, Qi Wang, Yijia Chen, Pengmin Li, Changhai Liu*, Fengwang Ma*. 2023. Overexpression of the FERONIA receptor kinase MdMRLK2 enhances apple cold tolerance. The Plant Journal . 115: 236-252.
(19) Tianli Guo, Zehua Yang, Ru Bao, Xiaomin Fu, Na Wang, Changhai Liu*, Fengwang Ma*. 2023. The m6A reader MhYTP2 regulates the stability of its target mRNAs contributing to low nitrogen tolerance in apple ( Malus domestica ). Horticulture Research . 10(6), doi.org/10.1093/hr/uhad094.
(18) Tianli Guo, Ru Bao, Zehua Yang, Xiaomin Fu, Liu Hu, Na Wang, Changhai Liu*, Fengwang Ma*. 2023. The m6A reader MhYTP2 negatively modulates apple Glomerella leaf spot resistance by binding to and degrading MdRGA2L mRNA. Molecular Plant Pathology . doi.org/10.1111/mpp.13370.
(17) Yuanyuan Jing, Minghui Zhan, Chunrong Li, Tingting Pei, Qi Wang, Pengmin Li*, Fengwang Ma*, Changhai Liu*. 2022. The apple FERONIA receptor-like kinase MdMRLK2 negatively regulates Valsa canker resistance by suppressing defense responses and hypersensitive reaction. Molecular Plant Pathology , doi.org/10.1111/mpp.13218.
(16) Qian Wang, Dong Huang, Wenyan Tu, Fengwang Ma*, Changhai Liu*. 2022. Overexpression of auxin/indole-3-acetic acid gene MdIAA24 enhances Glomerella leaf spot resistance in apple ( Malus domestica ). Horticultural Plant Journal, doi.org/10.1016/j.hpj.2022.12.011.
(15) Qian Wang#, Changhai Liu#, Dong Huang, Qinglong Dong, van Nocker S, Pengmin Li*, Fengwang Ma*. 2020. Physiological evaluation of nitrogen use efficiency of different apple cultivars under various nitrogen and water supply conditions. Journal of Integrative Agriculture , 19(3): 709-720.
(14) Yuerong Liu#, Lulu Yang#, Danyan Luo, Ziyan Mou, Changhai Liu*, Fengwang Ma*. 2024. The HD-Zip I transcription factor MdHB-7 negatively regulates Valsa canker resistance in apple ( Malus domestica ). Scientia Horticulturae. 324,112623.
(13) Chunrong Li#, Yuanyuan Jing#, Liang Cheng#, Zeguang Si, Ziyan Mou, Dongshan Niu, Fengwang Ma#, Changhai Liu#. 2023. The antifungal activity of trans-cinnamic acid and its priming effect in apple in response to Valsa mali. Plant Pathology. DOI: 10.1111/ppa.13786.
(12) Qian Wang, Dong Huang, Dongshan Niu, Jie Deng, Fengwang Ma*, Changhai Liu*. 2021.Overexpression of auxin response gene MdIAA24 enhanced cadmium tolerance in apple ( Malus domestica ). Ecotoxicology and Environmental Safety , 225: 112734.
(11) Tingting Sun#, Tingting Pei#, Lulu Yang, Zhijun Zhang, Mingjun Li, Yuerong Liu, Fengwang Ma*, Changhai Liu*. 2021. Exogenous application of xanthine and uric acid and nucleobase-ascorbate transporter MdNAT7 expression regulate salinity tolerance in apple. BMC Plant Biology , 21:52.
(10) Tianli Guo, Xiuzhi Zhang, Yuxing Li, Chenlu Liu, Na Wang, Qi Jiang, Junyao Wu, Fengwang Ma*, Changhai Liu*. 2020. Overexpression of MdARD4 accelerates fruit ripening and increases cold hardiness in tomato. International Journal of Molecular Science , 21, 6182; doi: 10.3390/ijms21176182.
(9) Changhai Liu, Tianli Guo, Na Wang, Qian Wang, Yangchun Xue, Minghui Zhan, Qingmei Guan, Fengwang Ma*. 2019. Overexpression of MhYTP2 enhances apple water-use efficiency by activating ABA and ethylene signaling. Environmental and Experimental Botany , 157: 260-268.
(8) Tianli Guo, Na Wang, Yangchun Xue, Qingmei Guan, Steven van Nocker, Changhai Liu*, Fengwang Ma*. 2019. Overexpression of the RNA binding protein MhYTP1 in transgenic apple enhances drought tolerance and WUE by improving ABA level under drought condition. Plant Science , 280: 397-407.
(7) Qian Wang#, Changhai Liu#, Dong Huang, Qinglong Dong, Pengmin Li*, Fengwang Ma*. 2019. High-efficient utilization and uptake of N contribute to higher NUE of ‘Qinguan’ apple under drought and N-deficient conditions compared with ‘Honeycrisp’. Tree Physiology , 11: 1880-1895.
(6) Qian Wang#, Changhai Liu#, Qinglong Dong, Dong Huang, Cuiying Li, Pengmin Li*, Fengwang Ma*. 2018. Genome-wide identification and analysis of apple NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family (NPF) genes reveals MdNPF6.5 confers high capacity for nitrogen uptake under low-nitrogen conditions. International Journal of Molecular Sciences , 19, 276.
(5) Chao Li, Qi Zhao, Tengteng Gao, Hongying Wang, Zhijun Zhang, Bowen Liang, Zhiwei Wei, Changhai Liu*, Fengwang Ma*. 2018. The mitigation effects of exogenous melatonin on replant disease in apple. Journal of Pineal Research . 65(4). e12523.
(4) Tingting Sun, Tingting Pei, Zhijun Zhang, Mingjun Li, Linlin Huang, Cuiying Li, Xueyan Shi, Minghui Zhan, Xiaoyu Cao, Fengwang Ma*, Changhai Liu*. 2018. Activated expression of PHT genes contributes to osmotic stress resistance under low phosphorus levels in Malus . Journal of the American Society for Horticultural Science . 143(6): 436-445.
(3) Changhai Liu, Carsten Pedersen, Torsten Schultz-Larsen, Aguilar BG, Madriz-Orderana K, Hovmoller SM, Hans Thordal-Christensen*. 2016. The stripe rust fungal effector PEC6 suppresses pattern-triggered immunity in a host species-independent manner and interacts with adenosine kinases. New Phytologist . doi.org/10.1111/nph.14034
(2) Changhai Liu, Chao Li, Dong Liang, FengwangMa*, Shuncai Wang, Ping Wang, Rongchao Wang. 2013. Aquaporin expression in response to water-deficit stress in two Malus species: relationship with physiological status and drought tolerance. Plant Growth Regulation , 70: 187-197.
(1) Changhai Liu, Chao Li, Dong Liang, Zhiwei Wei, Shasha Zhou, Rongchao Wang, FengwangMa*. 2012. Differential expression of ion transporters and aquaporins in leaves may contribute to different salt tolerance in Malus species. Plant Physiology and Biochemistry , 58: 159-165. doi: 10.1111/nph.14034.
6. 联系方式
通讯地址：陕西省杨凌示范区邰城路3号维多利亚vic115优惠大厅
邮编：712100
E-mail: chliu@nwafu.edu.cn; Lch198702@163.com;
